Olanzapine and Weed: Is it A Dangerous Combo?

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    Olanzapine and Weed (Brand Name Zyprexa)


    Olanzapine is classified as an atypical antipsychotic medication and is primarily used to help control schizophrenic symptoms and bipolar disorder. Certain, inconclusive studies have shown that Zyprexa and weed may be a dangerous combination.

    This article will summarize the studies concerning cannabis use and Olanzapine. More importantly, I will give you references that you can use to help you make your own decisions.

    Why There is Uncertainty

    Marijuana has been classified as a class one controlled substance by the United States federal government. Other class one drugs are heroin, LSD, and Peyote. Class one drugs are considered by the U.S. Government as having no medical uses. Because of the illegal nature of cannabis, it is increasingly difficult to study any medical benefits of cannabis. So, studies concerning cannabis are generally inconclusive. For example, there are few clinical trials using cannabis, a placebo, and other scientific methods.

    I do not know if the following video is accurate. However, it is interesting to look at and it could give you an idea of what the symptoms are for this psychiatric disorder.

    What Causes Schizophrenia

    The cause of schizophrenia is not known. One theory is that this affliction is caused by your brain producing too much dopamine. Scientists have said that it could be caused by several factors. (I.E., Environmental, Physical, Genetic, and psychological conditions) So, the exact cause is unknown and further evaluation is beyond the scope of this post.

    What is Olanzapine?

    Olanzapine is an antipsychotic drug that is prescribed for the treatment of psychological disorders like bipolar disorder and schizophrenia. The central disabling part of Schizophrenia patients is hallucinations or psychosis where they may not be able to know what is real and what isn’t real. Some of the other symptoms of schizophrenia are depression, mania, and different various other mental health abnormalities.

    • Use-Olanzapine helps reduce hallucinations, allows you to think clearly, control your anger, and will enable you to be part of mainstream society.
    • Drug Class- Atypical Antipsychotic
    • How Does It Work? In laymen’s terms, it works by helping get certain substances in your brain balanced.
    • Other Names: Zyprexa
    • Common Side Effects: Low blood pressure, sleepiness, weight gain, constipation, etc. Click Here, for the full list.
    • Dementia: May not be recommended for older adults (or younger) suffering from cognitive impairment caused by dementia.
    • Potential Drug Interactions: Click Here for the full list
    • Similar to other antipsychotic drugs like Clozapine and Geodon.

    Weed and Schizophrenia

    Since Olanzapine helps with schizophrenia symptoms, I felt it would be wise to briefly review the link (if any) between cannabis and schizophrenia. First of all, there is no conclusive link that cannabis causes schizophrenia or other permanent psychological ailments. However, there are have been studies that cannabinoid use can either worsen schizophrenia or bring it on quicker.

    Schizophrenia and Cannabis

    Per WebMD, cannabis is the most commonly used drug among schizophrenic patients. If you were to jump to conclusions, you might conclude that marijuana caused schizophrenia. However, this would be jumping the gun as schizophrenics may smoke cannabis as a form of self-medication. WebMD even admits this is plausible. (They also claim that self-medicating is unlikely the sole reason for the link between schizophrenia and weed)

    As I stated, I am not a Doctor. Cannabis is federally a class one, controlled substance, which means there have been few studies concerning the medicinal uses for cannabis. As a result, it is hard to know whether or not cannabis use caused schizophrenia or if it helped reduce the psychotic symptoms of schizophrenia. It essentially a chicken or the egg argument.

    Studies Are Inconclusive

    The studies linking schizophrenia and cannabis are inconclusive. WebMD even admits this by suggesting that there only “MAY” be a link between cannabis and the worsening of schizophrenic symptoms. Please note, I am not saying that there is not a link. I am saying that the link has not been proven, as there have not been any clinical studies on this subject. So, if you have any questions, you need to take them to a medical professional.

    If you are worried about telling your Doctor that you smoke cannabis, you should consider paying for a telemedicine service that will allow you to tell an out-of-state Doctor your concerns.

    What Is Known

    Makes Symptoms Worse And Can Bring It On Quicker

    The signs of schizophrenia tend to start later in life, for its sufferers. For males, the symptoms tend to first appear when they are in their late teens to early 20s. Women tend to start noticing schizophrenia symptoms from the late 20s to the early 30s. It is thought by some that cannabis use can cause the symptoms to appear quicker in life for both males and females that are prone to schizophrenia. WebMD even states that it can cause the symptoms to start three years earlier than it would have if you didn’t smoke cannabis.

    Too Young To Smoke?

    It has also been theorized that the earlier you start smoking cannabis (teen and pre-teen years), the more chance you may have to be afflicted with this form of mental illness.

    However, the link is inconclusive as the exact cause of schizophrenia is unknown. In summary, it cannot be concluded whether or not teen cannabis users with schizophrenia was caused by the cannabis or whether they would have gotten it even if they didn’t smoke weed.


    Olanzapine And Weed

    Some studies show that weed smokers who take weed and Olanzapine may suffer increased side effects and other negative symptoms from combining the two. It is not as simple as quitting cannabis if you want to be sure to get Olanzapine’s full benefits. The reason is that many smokers may exhibit adverse symptoms when they suddenly quit using weed when on olanzapine.

    The moral of the story is that you need to tell your Doctor you smoke weed or tobacco and feel that you’d like to quit.

    CBD And Schizophrenia

    There have been studies showing that cannabidiol (“CBD”) use can improve schizophrenic symptoms, which is promising because CBD also has fewer side effects than those who take traditional antipsychotic pharmaceuticals.


    There is no conclusive evidence upon whether or not Olanzapine and weed are a dangerous combo. As I am not a medical professional, I am not going to make any recommendations about whether you should continue smoking while taking this drug. Because of the lack of studies on cannabis, two Doctors may say two different things when asked if weed causes an adverse reaction with Olzaenpine or any other drug.

    So, my advice is to your research and consult professionals if you have schizophrenia, you suffer from any psychotic disorder, or if your family has a history of mental illness. I will advise you though to do your research, and you should definitely tell your psychiatrist that you do smoke cannabis. If you feel uncomfortable telling your shrink that you smoke, you should look for another doctor.

    Further Cannabis Medicinal And Supplement Interactions Information

    Doxycycline and Weed

    ZZZquil and Weed

    5HTP and Weed

    Accutane and Weed


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