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Olanzapine and Weed: Is it A Dangerous Combo?

Olanzapine and Weed

Olanzapine and Weed


Olanzapine is an antipsychotic medicine that is used to help Control schizophrenic symptoms. Certain, inconclusive studies have shown that Olanzapineand marijuana may be a dangerous combination. This article will summarize the studies on if you should take Olanzapine if you are on weed. More importantly, I will give you references that you can use to help you make your own decisions.

Why There is Uncertainty

Marijuana has been classified as a class one controlled substance by the United States federal government. Other class one drugs are heroin, LSD, and Peyote. Class one drugs are considered by the U.S. Government as having no medical uses.

Because of the illegal nature of cannabis, it is increasingly difficult to study cannabis’s medical use. So, studies concerning cannabis are generally inconclusive.
Therefore, two Doctors may say two different things when asked if weed causes an adverse reaction with Olzaenpine or any other drug. So, my advice is to your research and consult professionals if you have schizophrenia or any form of mental illness or if your family has a history of schizophrenia.

What is Olanzapine?

Olanzapine is an antipsychotic drug that is prescribed for the treatment of psychological disorders like bipolar mania, Bipolar related agitation, and schizophrenia. The central disabling part of Schizophrenia patients is hallucinations. They may not be able to know what is real and what isn’t real. Some of the other symptoms of schizophrenia are depression, mania, different various other mental health abnormalities.

  • USE: Olanzapine helps reduce hallucinations, allows you to think clearly, control your anger, and will enable you to be part of mainstream society.
  • Drug Class: Antipsychotics
  • How Does It Work? In laymen’s terms, it works by helping get certain substances in your brain balanced.
  • Other Names: Zyprexa, Zyprexa Relprevv, Zyprexa Zydis

Weed and Schizophrenia

Since Olanzapine helps with schizophrenia symptoms, I felt it would be wise to briefly review the link (if any) between cannabis and schizophrenia. First of all, there is no conclusive link that cannabis causes schizophrenia or other permanent psychological ailments. However, there are have been studies that marijuana can either worsen schizophrenia or bring it on quicker.

What Causes Schizophrenia

The cause of schizophrenia is not known. However, scientists have said that it could be caused by several factors. (I.E., Environmental, Physical, Genetic, and psychological conditions.

Schizophrenia and Cannabis

Per WebMD, cannabis is the most commonly used drug among schizophrenic patients. If you were to jump to conclusions, you might conclude that marijuana caused schizophrenia. However, this would be jumping the gun as schizophrenics may smoke cannabis as a form of self-medication. WebMD even admits this is plausible. (They also claim that self-medicating is unlikely the sole reason for the link between schizophrenia and marijuana)
As I stated, I am not a Doctor. Marijuana is federally a class one, controlled substance, which means there have been few studies concerning the medicinal uses for cannabis. As a result, it is hard to know whether or not cannabis use caused schizophrenia or if marijuana helps reduce the negative symptoms of schizophrenia, like hallucinating. It essentially a chicken or the egg argument.

Studies Are Inconclusive

The studies linking schizophrenia and cannabis are inconclusive. WebMD even admits this by suggesting that their only “MAY” be a link between cannabis and the worsening of schizophrenic symptoms.
Please note, I am not saying that there is not a link. I am saying that the link has not been proven, and if you have any questions, you need to take to a medical professional.

If you are worried about telling your Doctor that you smoke cannabis, you should consider paying for a telemedicine service that will allow you to tell an out-of-state Doctor your concerns.

What Is Known

Makes Symptoms Worse

There are studies which indicate that, for those who have been diagnosed with schizophrenia, marijuana can worsen its symptoms. As a result, if your symptoms are aggravated, you will have more uncontrollable psychotic incidents. You may spend more time in the psych ward.

Brings It On Quicker

The signs of schizophrenia tend to start later in life, its sufferers. For man, the symptoms tend to first appear when they are in their late teens to early 20s. Women tend to start noticing schizophrenia symptoms from the late 20s to the early 30s. It is thought by some that cannabis use can cause the symptoms to appear quicker in life for both and women that are prone to schizophrenia. WebMD even states that it can cause the symptoms to start three years earlier than it would have if you didn’t smoke cannabis.

Too Young To Smoke?

It has also been theorized that the earlier you start smoking cannabis (teen and pre-teen years), the more chance you would have to get schizophrenia.

However, the link is inconclusive as the exact cause of schizophrenia is unknown. In summary, it cannot be concluded whether or not teen cannabis users with schizophrenia was caused by the cannabis or whether they would have gotten it even if they didn’t smoke weed.

CBD And Schizophrenia

There have been studies showing that CBD use can improve schizophrenic symptoms. CBD also has fewer side effects than those who take traditional antipsychotic pharmaceuticals.

Olanzapine is used to treat schizophrenic symptoms. I.e., Control or eliminate hallucinations. Some studies show that weed smokers who take Olanzapine can cause increased side effects for Olanzapineand other unwanted reactions.

It is not as simple as quitting cannabis if you want to be sure to get Olanzapine’s full benefits. The reason is that cannabis or tobacco smokers have exhibited adverse symptoms when they suddenly quit using weed or tobacco upon being prescribed olanzapine.

The moral of the story is that you need to tell your Doctor you smoke weed if you are suffering from cannabis.


There is no conclusive evidence upon whether or not Olanzapine and weed are a dangerous combo. Also, as it can be hazardous, going cold turkey and quitting marijuana because of being prescribed Olanzapine can be hazardous.
As I am not a medical professional, I am not going to make any recommendations about whether you should continue smoking while taking Olanzapine. I will advise you though to do your research, and you should definitely tell your psychiatrist that you do smoke cannabis. If you feel uncomfortable telling your shrink that you smoke, you should look for another doctor.


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