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Nyquil, ZZZQUIL and WEED-Bad News?

Weed and Sleep Aid

ZZZQUIL And WEED- Nyquil, and Weed-Should They Be Combined?

Both Nyquil and ZZZQuil are made by Vicks, which is owned by Proctor and Gamble and Helen of Troy, limited.

Vicks specializes in OTC medications for the cold, flu, sleeping aids, congestion, coughs, sore throats, allergy relief, and more.

I am not a Doctor, and I have no medical training. This information here is gathered from various internet sources. Of course, if you have any medical questions, ask your doctor.

In this article, I will not discuss whether or not ZZZquil helps you get to sleep quicker or if Nyquil will help you with your flu and cold symptoms. I will, though, examine if it is wise to combine weed and ZZZQUIL or weed and Nyquil.

First, I will briefly explain both medicines.

ZZZQUIL and NYQUIL Fact Sheets


ZzzQuil, Nighttime Sleep Aid Liquid, 50 mg Diphenhydramine HCl, No.1 Sleep-Aid Brand, Warming Berry Flavor, Non-Habit Forming, 12 FL OZ

ZZZYQUIL is marketed as a non-habit-forming, sleep medication that is to be used for an occasional sleeping problem, and not for a chronic sleep disorder like insomnia.

ZZZQUIL Ingredients

ZZZQUIL’s active ingredient that will make you sleepy is Diphenhydramine HC. (Diphenhydramine-HC is also the main ingredient of the over-the-counter allergy medicine Benadryl) ZZZQUIL also has several inactive ingredients that were added for looks and flavoring.

Some of the inactive ingredients are food coloring, citric acid, and high fructose corn syrup. Diphenhydramine HC is ZZZQUIL’s only active, listed ingredient. Therefore, I will briefly examine the side effect and potential dangers of this drug.

Diphenhydramine HC Side Effects

First of all, every prescription and OTC medicine has potential side effects. For example, taking aspirin can potentially cause pulmonary edema. And even certain foods can cause an adverse reaction with certain drugs.

So, Just because a drug can cause specific reactions does not mean that it is faulty. It also doesn’t mean that the drug is also safe.

According to WebMD, the non-lethal side effects of Diphenhydramine HC are drowsiness, dizziness, upset stomach, constipation, vision problems, dry mouth, dry throat, and a dry nose.

Some of the extremely rare and potentially deadly reactions to Diphenhydramine HC are restlessness, confusion, urination problems, and Tachycardia. (When your heartbeats too fast) Also, seizures have been reported.

Nyquil Fact Sheet

Vicks NyQuil SEVERE, Nighttime Relief of Cough, Cold & Flu Relief, Sore Throat, Fever, & Congestion Relief, Berry Flavor, Twin Pack, 12 FL OZ

The Nyquil product line, whose main competitor is Robitussin, is designed to help control flu, and cold symptoms like cough, sore throat, congestion, headaches, etc. And, as you likely guessed, Nyquil also has a sedative effect.

For a non-sedative effect, choose Vick’s Dayquil.

Nyquil’s Ingredients

Unlike ZZZQUIL, Nyquil has several active ingredients that are listed below.

Acetaminophen (AKA “Tylenol”)

Ues: A pain reliever, like that, provides pain relief from minor aches and pains, fever, headaches, etc.

Main Side Effects: Nausea, stomach pain, loss of appetite, and high doses can cause liver damage

Dextromethorphan HBr (“DXM”)

Uses: Is a cough suppressant

Main Side Effects: Dizziness, sleepiness, stomach problems, restlessness

Doxylamine Succinate

Uses: It is an antihistamine used to promote sleep, and also provide allergy symptom relief

Main Side Effects: Drowsiness

Phenylephrine HCl (Not Always included)

Uses: It is a decongestant designed to help with symptoms like a runny nose.

Main Side Effects: Dizziness, headaches, GI problems like an upset stomach

Nyquil Addiction

Prolonged use of Nyquil can result in addiction that could result in withdrawal symptoms.

How Is Nyquil Different From ZZZquil?

ZZZQUIL, differs from its more famous cousin NYQUIL, in that it is ONLY designed to help you get to sleep quicker and not meant to be cold medicine, pain reliever, and so forth.

Nyquil, though, is designed to help with common cold and flu symptoms. (I.E. Sore throat, Cough Suppressant, Pain Relief, etc.)


Cannabis Study Limitations

As I have stated numerous times, cannabis is a schedule 1 drug, which means there have been very few medical studies concerning cannabis.

As a result, there is limited information concerning ZZZQUIL and Nyquil’s main ingredients’ interaction with weed.

Weed and ZZZQUIL’s Dangers

Some of the information, primarily from addiction recovery websites, concerning cannabis and Diphenhydramine HC (ZZZQUIL’s active ingredient) is hysteria.

For example, Diphenhydramine HC has caused Tachycardia. An addiction recovery website, without any evidence, stated that combining the two could result in an increased risk of Tachycardia. However, they provide no evidence or studies to back this claim up.

Nyquil and Weed Potential Dangers

For Nyquil, the best resource that I can find on weed and Nyquil’s interactions were from Healthline. This article did not specifically mention Nyquil. It did however mention cold and flu, OTC medications.

Nyquil is the most well-known, OTC cold and flu medicine in the US. So, It would not be a brash assumption that Nyquil is applicable for their advice.

Healthline did not outright state that smoking weed while on OTC cold medication was a mistake. It did mention that weed and Nyquil might enhance some of the common side-effects that are associated with weed. I.E. Sedation.

What was noteworthy, that this article stated that regular cannabis users should not stop smoking weed when taking OTC cold medicine. Instead, they should just not smoke any more than they normally would smoke.

Enhances Effects

The most reliable source concerning the dangers of combining Nyquil and ZZZyquill with weed came from and Healthline.

Both of these articles stated that the active ingredients of Nyquil and ZZZquill combined with smoking weed can increase the side effects that are common with both Nyquil or ZZZquills and cannabis. For example, dizziness, drowsiness, and the ability to concentrate will able be accelerated when you are smoking pot and taking Nyquil.

One of these effects, drowsiness, is what the users of ZZZQuil and Nyquil are wanting to achieve, which is sleep. And some of the other effects are not an issue when you are sleeping. For example, concentration is not a desired trait to have when you want to get some shut-eye.

Final Thoughts

From what I have read, the recommended dose of ZZZquil combined with weed should not be dangerous. Depending upon what that you smoke, it also can potentially make you go to sleep quicker.

A realistic danger though is that combining ZZZquil or Nyquil and pot could be dangerous if you have to get up in an emergency during the night. However, you’d have that same issue with alcohol use, opioid pain killers, or if you were taking other types of sleeping medicines

My personal views on combining these two make me ask this question: Why?

ZZZQUIL or Nyquil, when used sparingly, should be enough to help you get to sleep. So, adding cannabis is unnecessary and merely wasting good weed. If you have a problem sleeping, save you money and your weed, as there is no use using both.

Further Cannabis Medicinal Interactions Articles

Olazanpine and Weed

Doxycycline and Weed



Further Cannabis Medicinal Interactions Articles

Olazanpine and  Weed

Doxycycline and Weed


Written by ganjashark

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